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  Tnfaip8 and Tipe2 Gene Deletion Ameliorates Immediate

  Here, we examined the effects of TNFAIP8/TIPE2 deficiency on the IVDs in mice with these genes deleted. Design: Tail IVDs in Tnfaip8 or Tipe2 single and double knockout mice (Tnfaip8-/-, Tipe2-/-, and Tnfaip8/Tipe2 dko), and wild type (WT) controls were injured. The spine motion segments were stained with Safranin O to reveal proteoglycans.

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  In Silico Study of Potential Small Molecule TIPE2 Inhibitors …

  Oct 7, 2023 · Context: Chronic inflammation has been linked to cancer since the 19th century. Tumor growth is supported by the proangiogenic factors that chronic inflammation requires. Polarized leukocytes initiate these angiogenic and tumorigenic factors. TIPE2, a transport protein, manages the cytoskeletal rearrangement that gives a polarized leukocyte its motility. Inhibition …

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  : TIPE2 ...

  TIPE2 8（TNFAIP8TIPE），。，MDSCsTIPE2。，IL-6

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  α82

  Dec 21, 2018 · TIPE2，TIPE2，T（T ） [14]，BB [15]。TIPE2，， ...

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  ELISA--

  Oct 25, 2023 · -α8-2(TIPE2)4(IL-4)(ATM) 。 、WesternPCR(RT-qPCR)TIPE2(KO) ...

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  TIPE2 knockdown exacerbates isoflurane-induced …

  Apr 11, 2023 · TIPE2 deficiency induced microglial activation and increased secretion of proinflammatory cytokines. In addition, TIPE2 deficiency promoted STAT3 and NF-κB signaling activation induced by isoflurane anesthesia and after surgery. Conclusion: TIPE2 may play a neuroprotective role in POCD by regulating STAT3 and NF-κB pathways.

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  The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays …

  Drawing upon prior research conducted in our laboratory, it has been demonstrated that tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) performs a protective function in septic lung injury and septic encephalopathy by suppressing the NF-κB and MAPK pathways. Hence, we hypothesized that TIPE2 might be a target protein of OTUD1.

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  （、 ...

  ，19635，、，，、、“”，，、； …

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  Increased expression of TIPE2 in alternatively activated

  Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disorder characterized by exaggerated local immune responses. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a novel protein with potential immune modulating function. The expression and function of TIPE2 in human airway diseases are unclear.

  TIPE2 ...

  。 ， ，1~5，，~

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